ZO Skin Health Growth Factor Face Serum

ZO Skin Health Growth Factor Serum is an advanced gel serum powered by next-generation growth factor technology to visibly improve skin density, firmness, and overall youthful appearance. Designed for aging skin experiencing loss of elasticity, lines, and wrinkles, this formula works to strengthen the skin and support its natural structure for smoother, more resilient-looking skin.

At the core of this formula is an innovative blend of five human-comparable growth factors (IGF-1, EGF, acidic FGF, basic FGF, and VEGF). These growth factors are safely bio-engineered using microbial fermentation, a controlled lab process where beneficial proteins are produced without the use of human or animal tissue. This ensures a high level of purity, consistency, and safety, while delivering growth factors that closely mimic those naturally found in healthy, youthful skin.

Together, these targeted growth factors help support the skin’s foundational components, improve the appearance of thickness and elasticity, and reinforce the integrity of the extracellular matrix for long-term rejuvenation.

Clinically shown to deliver visible results:

• Improves the appearance of skin thickness and elasticity in as little as 8 weeks
• Helps reduce the look of fine lines and wrinkles
• Enhances skin firmness, smoothness, and overall vitality
• Users reported skin appearing nearly 6 years younger after 8 weeks

Features and Benefits:

• Strengthens and supports the skin barrier
• Restores hydration for a plumper, more supple appearance
• Improves the look of lines, wrinkles, and loss of density
• Helps protect against future signs of aging
• Promotes healthier-looking, more resilient skin

Key Ingredients:

• Human-Comparable Growth Factors: Bio-identical growth factors produced via advanced fermentation technology to support skin rejuvenation and visible anti-aging benefits
• Disodium Acetyl Glucosamine Phosphate: Helps restore hydration and improve the appearance of plumpness, thickness, and elasticity
• Lactobacillus/Panax Ginseng Root Extract (Fermented Red Ginseng): Helps reduce the appearance of lines and wrinkles while supporting skin vitality
• Dipeptide Diaminobutyroyl Benzylamide Diacetate: Helps soften the appearance of expression lines for a smoother look
• ZPRO® Biomimetic Protein Complex: Supports hydration and helps defend against future signs of aging

Ideal for those looking to address visible aging while supporting long-term skin health, ZO Growth Factor Serum delivers clinically backed results with cutting-edge, ethically developed biotechnology.

Apply ZO Skin Health Growth Factor Serum morning and evening as part of your daily skincare regimen.

1. Prepare: Cleanse, exfoliate, and tone using your Getting Skin Ready® products as appropriate for your skin.
2. Strengthen: Apply Daily Power Defense or other prescribed treatment products.
3. Correct: Apply 1–2 pumps of Growth Factor Serum evenly to the face and neck, gently smoothing into the skin.
4. Protect: In the morning, finish with a broad-spectrum sunscreen SPF 40 or higher.

Growth Factor Serum is generally applied last among ZO Prevent + Correct products. Consistent twice-daily application is recommended for optimal results, with visible improvements developing over several weeks.

Aqua/Water/Eau, Dimethicone, Butylene Glycol, Glycerin, Caprylyl Methicone, Dimethicone/PEG-10/15 Crosspolymer, PEG-12 Dimethicone/PPG-20 Crosspolymer, Dimethicone/Vinyl Dimethicone Crosspolymer, 1,2-Hexanediol, Caprylyl Glycol, Sodium Hyaluronate, Sodium Chloride, Dimethicone Crosspolymer, Lactobacillus Ferment, Scutellaria Baicalensis Root Extract, Sodium Citrate, Hydrolyzed Sericin, Phospholipids, Acetyl Glutamine, Lecithin, Buddleja Davidii Meristem Cell Culture, Cordyceps Militaris Mycelium Extract, Glycyrrhiza Uralensis (Licorice) Root Extract, Dipropylene Glycol, Pentylene Glycol, Xanthan Gum, Beta-Glucan, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Lactobacillus/Panax Ginseng Root Ferment Filtrate, Hexylene Glycol, Phenoxyethanol, Potassium Sorbate, Tocopherol, Disodium Acetyl Glucosamine Phosphate, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-11, Sh-Polypeptide-9, Bacillus/Folic Acid Ferment Filtrate Extract, Hexamethylindanopyran, Terpineol, Tetramethyl Acetyloctahydronaphthalenes, Fragrance/Parfum.

We are continually innovating and adapting to new regulations. As a result, depending on when and where the product was purchased, the ingredient lists on this website may differ from product packaging. Please refer to your product packaging for ingredient information specific to your product.

About ZO Skin Health

Founded by world-renowned dermatologist Dr. Zein Obagi, ZO Skin Health is a leader in medical-grade skincare, combining advanced dermatological science with innovative ingredients and clinically informed formulations. Built on the philosophy that healthy skin is the foundation of beautiful skin, ZO develops comprehensive skincare solutions designed to improve skin function, address visible signs of aging, and support long-term skin health.

From advanced retinol treatments and antioxidant serums to pigment-correcting products, growth factor technology, and daily sun protection, ZO Skin Health offers targeted solutions for a wide range of skin types and concerns.

Shop Authentic ZO Skin Health at Rejuvent

Rejuvent Skincare is an authorized ZO Skin Health retailer, offering 100% authentic products through our physician-directed skincare practice, led by Dr. Kelly Bomer, MD.

Select ZO Skin Health products are available for online purchase through our Rejuvent VIP+ program. Our team can assist with product recommendations, eligibility, and personalized skincare regimens.

Join our VIP Program now

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What does ZO Skin Health Growth Factor Serum do?

ZO Growth Factor Serum helps improve the visible signs of aging associated with declining skin density, elasticity, and firmness. Its advanced growth-factor technology supports the skin's structural foundation while improving the appearance of fine lines, wrinkles, smoothness, and hydration.

What is new about ZO Growth Factor Serum 2.0?

The reformulated serum features five human-comparable growth factors, combined with plant- and enzymatically-derived ingredients and ZO's ZPRO® biomimetic protein complex. This next-generation technology is designed to improve the appearance of skin density, elasticity, and overall resilience.

How long does ZO Growth Factor Serum take to work?

Some users may notice improved hydration and smoother-feeling skin within two weeks. In ZO's clinical study, participants reported visible improvements after eight weeks of twice-daily use, with additional improvements evaluated through 12 weeks. Individual results vary.

Can I use ZO Growth Factor Serum with retinol?

Yes. Growth Factor Serum can be incorporated into a skincare regimen containing retinol. Follow your individualized ZO protocol for application order, frequency, and tolerability. Consistent sun protection is important when using retinol-containing skincare.

Is ZO Growth Factor Serum suitable for all skin types?

ZO identifies Growth Factor Serum as suitable for all skin types. It is particularly relevant for mature skin experiencing visible thinning, loss of elasticity, fine lines, and reduced firmness.

Is ZO Growth Factor Serum made from human tissue?

No. The human-comparable growth factors are synthesized using biotechnology rather than harvested from human tissue. They are designed to resemble growth factors naturally found in human skin.

Why is ZO Growth Factor Serum restricted to VIP+ customers at Rejuvent Skincare?

ZO Growth Factor Serum is a physician-channel skincare product. Rejuvent Skincare provides access through its VIP+ purchasing process in accordance with its authorized retail arrangements.